Midnight Express is the 6th area that appears in the game Cactus McCoy and the Curse of Thorns. It is one of three areas that take place in a train. Other train areas in this game are Rustler Railroad and Deadridge Railway.
- Chicken Train Rumble: Reach the train following yours, and finish the Rumble with the Enemigos.
- Full Steam Ahead: Beat the level in 2:00.
- Break up the Band: Kill all Guitar Enemigos with Banjos.
- Crack That Whip: Take out 3 whip-wielding Enemigos with whips.
- Check Your Luggage: Throw all luggage trunks off the train.